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Article

Role of the Ubiquitin Proteasome System in the Heart

28 Mar 2013

Abstract excerpt

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3...

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PMID: 23538275
DOI: 10.1161/circresaha.112.300521

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