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APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points

21 May 2019

Abstract excerpt

There are conflicting results regarding how APOE genotype, the strongest genetic risk factor for Alzheimer's disease (AD), influences spatial and longitudinal amyloid-β (Aβ) deposition and its impact on the selection of biomarker cut-points. In our study, we sought to determine the impact of APOE genotype on cross-sectional and longitudinal florbetapir positron emission tomography (PET) amyloid measures and its...

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PMID: 31127775
DOI: 10.3233/jad-181282

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