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Article

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer-Predisposing Factors in Familial Early-Onset Colorectal Cancer.

The Kaohsiung journal of medical sciences - 1 Jul 2026

Bagheri Behnaz, Mohsen-Pour Neda, Salehi Najmeh, Moghadam Pardis Ketabi, Zeinalpour Adel, Sadeghi Amir, Kalayinia Samira, Fatemi Nayeralsadat

Abstract excerpt

Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood. This paper aims to examine novel genetic variants associated with CRC in Iranian patients. We performed whole-exome sequencing (WES) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41479393
DOI: 10.1002/kjm2.70166
PMCID: PMC13344276

Genes

ERBB2
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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