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Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases.

World journal of gastroenterology - 14 Apr 2015

Zhang Jun-Xiao, Fu Lei, de Voer Richarda M, Hahn Marc-Manuel, Jin Peng, Lv Chen-Xi, Verwiel Eugène Tp, Ligtenberg Marjolijn Jl, Hoogerbrugge Nicoline, Kuiper Roland P, Sheng Jian-Qiu, Geurts van Kessel Ad

Abstract excerpt

AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer (CRC) predisposing genes in early-onset or familial CRC cases. METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with non-polyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 first-degree relative...

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Identifiers

PMID: 25892863
DOI: 10.3748/wjg.v21.i14.4136
PMCID: PMC4394074

Genes

MLH1
MSH2
MUTYH

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