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Article

The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation.

Diabetes - 1 May 2021

Liang Xuehua, Duan Hualin, Mao Yahui, Koestner Ulrich, Wei Yiqiu, Deng Feng, Zhuang Jingshen, Li Huimin, Wang Cunchuan, Hernandez-Miranda Luis R, Tao Weihua, Jia Shiqi

Abstract excerpt

The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. The insulinoma-associated protein 1 (Insm1), which encodes a protein containing one SNAG domain and five zinc fingers, plays essential roles in pancreatic endocrine cell...

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PMID: 33547047
DOI: 10.2337/db20-0883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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