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Second-Generation Neuroendocrine Immunohistochemical Markers: Reflections from Clinical Implementation

5 Sept 2021

Abstract excerpt

When analyzing tumors by histopathology, endocrine pathologists have traditionally been restricted to a few key immunohistochemical markers related to secretory vesicles in order to pinpoint neuroendocrine differentiation-most notably Chromogranin A (CGA) and Synaptophysin (SYP). Although proven of great clinical utility, these markers sometimes exhibit tissue-specific patterns depending on tumor origin, and...

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PMID: 34571751
DOI: 10.3390/biology10090874

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