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Article

Transcriptomic profiling of insulinomas reveals a new "low-endocrine" subtype with low YY1 expressions.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 May 2026

Li Yongzheng, Zhang Xingwu, Xu Qiang, Han Xianlin, Guo Dan, Jiao Yixi, Zhang Hao, Yin Bohui, Hong Xiafei, Wu Wenming

Abstract excerpt

BACKGROUND: Insulinoma is the most common functional pancreatic neuroendocrine tumors, typically originating from pancreatic β cells. However, the transcriptional heterogeneity and the regulatory role of transcription factor YY1 remain incompletely understood. METHODS: High-throughput bulk-RNA sequencing was conducted on insulinoma tumor samples. Unsupervised clustering algorithms were employed to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41748371
DOI: 10.1016/j.pan.2026.02.006

Genes

YY1
INS
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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