Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

The Journal of cell biology - 5 Jun 2006

Pellinen Teijo, Arjonen Antti, Vuoriluoto Karoliina, Kallio Katja, Fransen Jack A M, Ivaska Johanna

Abstract excerpt

Dynamic turnover of integrin cell adhesion molecules to and from the cell surface is central to cell migration. We report for the first time an association between integrins and Rab proteins, which are small GTPases involved in the traffic of endocytotic vesicles. Rab21 (and Rab5) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Membrane
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Green Fluorescent Proteins

Share to Integrin beta1

Share to Protein Transport

Share to rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16754960
DOI: 10.1083/jcb.200509019
PMCID: PMC2063892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.PMID 16754960Read ↗

GGA2 and RAB13 promote activity-dependent β1-integrin recyclingSemantic proximity Read ↗

Integrin traffic – the updateSemantic proximity Read ↗

Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.Semantic proximity Read ↗

RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.Semantic proximity Read ↗

A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and 3D invasion of macrophagesSemantic proximity Read ↗

The complexity of integrins in cancer and new scopes for therapeutic targetingSemantic proximity Read ↗

Regulation and functions of integrin α2 in cell adhesion and diseaseSemantic proximity Read ↗

Integrin-mediated signals regulated by members of the rho family of GTPases.Semantic proximity Read ↗

Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.Semantic proximity Read ↗

A role for the small GTPase Rab21 in the early endocytic pathway.Semantic proximity Read ↗

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migrationSemantic proximity Read ↗

RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.