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Article

MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC

9 May 2019

Abstract excerpt

BACKGROUND: Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, the role of MED12 in non-small cell lung cancer (NSCLC) remains to be elucidated. METHODS: MED12 mutation was detected by Next-generation sequencing. The expression of MED12 in 179 human NSCLC...

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PMID: 31072327
DOI: 10.1186/s12943-019-1020-4

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