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Article

Tumour-suppression function of KLF12 through regulation of anoikis

12 Oct 2015

Abstract excerpt

Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell...

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PMID: 26455320
DOI: 10.1038/onc.2015.394

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