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RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation

29 Aug 2025

Abstract excerpt

BACKGROUND: RANBP9 and RANBP10, also called Scorpins, are essential components of the C-terminal to LisH (CTLH) complex, an evolutionarily conserved poorly investigated multisubunit E3 ligase. Their role in non-small cell lung cancer (NSCLC) is unknown. METHODS: In this study, first we used stable loss-of function and overexpression inducible cell lines to investigate the ability of either RANBP9 or RANBP10 to...

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PMID: 40883813
DOI: 10.1186/s13046-025-03491-8

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