Article

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

2023-04-21

Abstract excerpt

Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, lung adenocarcinoma (LUAD) cells transform into neuroendocrinal (NE) tumor cells. However, the mechanisms of NE cell plasticity remain unclear. CRACD, a capping protein inhibitor, is frequently inactivated in cancers. CRACD knock-out (KO) de-represses NE-related gene expression in the pulmonary epithel...

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Literature Corpus work: cb4b1335-6126-5d77-a568-ddca29d2a4b0
DOI: 10.1101/2023.04.19.537576

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