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Article

PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids

14 May 2018

Abstract excerpt

PRDM1 is a tumor suppressor that plays an important role in B and T cell lymphomas. Our previous studies demonstrated that PRDM1β is a p53-response gene in human colorectal cancer cells. However, the function of PRDM1β in colorectal cancer cells and colon tumor organoids is not clear. Here we show that PRDM1β is a p53-response gene in human colon organoids and that low PRDM1 expression predicts poor survival in...

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PMID: 29760071
DOI: 10.1073/pnas.1802902115

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