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Article

Microglia modulation by TGF-β1 protects cones in mouse models of retinal degeneration

30 Apr 2020

Abstract excerpt

Retinitis pigmentosa (RP) is a genetically heterogenous group of eye diseases in which initial degeneration of rods triggers secondary degeneration of cones, leading to significant loss of daylight, color, and high-acuity vision. Gene complementation with adeno-associated viral (AAV) vectors is one strategy to treat RP. Its implementation faces substantial challenges, however; for example, the tremendous number...

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PMID: 32352930
DOI: 10.1172/jci136160

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