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Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

2021-12-21

Abstract excerpt

Photoreceptor degeneration leads to irreversible vision loss in humans with retinal dystrophies such as Retinitis Pigmentosa. Whereas photoreceptor loss is permanent in mammals, zebrafish possesses the ability to regenerate retinal neurons and restore visual function. Following acute damage, Müller glia (MG) re-enter the cell cycle and produce multipotent progenitors whose progeny differentiate into mature neurons...

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Identifiers and source

Literature Corpus work
6fd54353-7f49-54f6-bf4b-39146e2e08a0
DOI
10.1101/2021.12.19.473212
Open publication

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Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophyDOI 10.1101/2021.12.19.473212
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