Structural basis of ligand recognition at the human MT1 melatonin receptor.

doi:10.1038/s41586-019-1141-3

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Article

Structural basis of ligand recognition at the human MT1 melatonin receptor.

Nature - 1 May 2019

Stauch Benjamin, Johansson Linda C, McCorvy John D, Patel Nilkanth, Han Gye Won, Huang Xi-Ping, Gati Cornelius, Batyuk Alexander, Slocum Samuel T, Ishchenko Andrii, Brehm Wolfgang, White Thomas A, Michaelian Nairie, Madsen Caleb, Zhu Lan, Grant Thomas D, Grandner Jessica M, Shiriaeva Anna, Olsen Reid H J, Tribo Alexandra R, Yous Saïd, Stevens Raymond C, Weierstall Uwe, Katritch Vsevolod, Roth Bryan L, Liu Wei, Cherezov Vadim

Abstract excerpt

Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as the regulation of blood pressure and core body temperature, oncogenesis, and immune function3. Melatonin is formed in the pineal gland in a light-regulated manner4 by enzymatic conversion from 5-hydroxytryptamine (5-HT or...

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PMID: 31019306
DOI: 10.1038/s41586-019-1141-3
PMCID: PMC6696938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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