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Article

Melatonin receptor signaling in human pathologies: from molecular mechanisms to therapeutic targets.

Function (Oxford, England) - 1 Jun 2026

Huang Yen-Sung, Wu Sheng-Ding, Chen Hsi-Chih, Lu Kuo-Cheng, Ka Shuk-Man, Wu Chia-Chao

Abstract excerpt

The melatonin receptor 1 A (MTNR1A), a highly conserved G protein-coupled receptor (GPCR), mediates crucial physiological functions. Its structure features an N-terminus responsible for melatonin binding and a C-terminus that initiates downstream signaling pathways to modulate target gene expression. Given MTNR1A's ability to form homodimers or heterodimers with other GPCRs, its expression levels are critical for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42139078
DOI: 10.1152/function.011.2026
PMCID: PMC13245880

Genes

MTNR1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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