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Article

The role of proline residues in the structure and function of human MT2 melatonin receptor.

Journal of pineal research - 1 Nov 2008

Mazna Petr, Grycova Lenka, Balik Ales, Zemkova Hana, Friedlova Eliska, Obsilova Veronika, Obsil Tomas, Teisinger Jan

Abstract excerpt

Melatonin functions as an essential regulator of various physiological processes in all vertebrate species. In mammals, two G protein-coupled melatonin receptors (GPCR) mediate some melatonin's actions: MT1 and MT2. Transmembrane domains (TM) of most GPCRs contain a set of highly conserved proline residues that presumably play important structural and functional roles. As TM segments of MT2 receptor display...

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Identifiers

PMID: 18544139
DOI: 10.1111/j.1600-079X.2008.00598.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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