Article
Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.
Translational psychiatry - 20 Feb 2023
Pignataro Annabella, Krashia Paraskevi, De Introna Margherita, Nobili Annalisa, Sabetta Annamaria, Stabile Francesca, La Barbera Livia, D'Addario Sebastian Luca, Ventura Rossella, Cecconi Francesco, D'Amelio Marcello, Ammassari-Teule Martine
Abstract excerpt
Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show an autistic-like phenotype associated with hippocampal circuits dysfunctions which include loss of parvalbuminergic interneurons (PV-IN), decrease in the inhibition/excitation ratio, and abundance of immature dendritic spines on CA1 pyramidal neurons. Given the paucity of data relating to female autism, we exploit the...
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