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Article

Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits.

Journal of neuroinflammation - 27 Sept 2024

Su Xi, Wang Guanyu, Liu Senqi, Li Jinming, Shao Minglong, Yang Yongfeng, Song Meng, Han Yong, Li Wenqiang, Lv Luxian

Abstract excerpt

Autophagy is crucial for synaptic plasticity and the architecture of dendritic spines. However, the role of autophagy in schizophrenia (SCZ) and the mechanisms through which it affects synaptic function remain unclear. In this study, we identified 995 single nucleotide polymorphisms (SNPs) across 19 autophagy-related genes that are associated with SCZ. Gene Set Enrichment Analysis (GSEA) of data from the Gene...

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Identifiers

PMID: 39334475
DOI: 10.1186/s12974-024-03235-z
PMCID: PMC11438297

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