Article

Isoform-specific characterization implicates alternative splicing in <i>APOBEC3B</i> as a mechanism restricting APOBEC-mediated mutagenesis

2020-09-27

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis, but the understanding of the regulation of their mutagenic activity remains limited. Here, we showed that mutagenic and non-mutagenic A3A and A3B enzymes are produced by canonical and alternatively spliced A3A and A3B isoforms, respectively. Notably, increased expression of the canonical A3B isoform, which encodes th...

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Literature Corpus work: e4908325-2c2f-566c-9a27-fdddc666c73e
DOI: 10.1101/2020.09.27.315689

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