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Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.

Cancer prevention research (Philadelphia, Pa.) - 2 Oct 2023

Rao Nina, Starrett Gabriel J, Piaskowski Mary L, Butler Kelly E, Golubeva Yelena, Yan Wusheng, Lawrence Scott M, Dean Michael, Garcia-Closas Montserrat, Baris Dalsu, Johnson Alison, Schwenn Molly, Malats Nuria, Real Francisco X, Kogevinas Manolis, Rothman Nathaniel, Silverman Debra T, Dyrskjøt Lars, Buck Christopher B, Koutros Stella, Prokunina-Olsson Ludmila

Abstract excerpt

FGFR3 and PIK3CA are among the most frequently mutated genes in bladder tumors. We hypothesized that recurrent mutations in these genes might be caused by common carcinogenic exposures such as smoking and other factors. We analyzed 2,816 bladder tumors with available data on FGFR3 and/or PIK3CA mutations, focusing on the most recurrent mutations detected in ≥10% of tumors. Compared to tumors with other...

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Class I Phosphatidylinositol 3-Kinases
Mutation
Urinary Bladder
Urinary Bladder Neoplasms

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PMID: 37477495
DOI: 10.1158/1940-6207.CAPR-23-0112
PMCID: PMC10592262

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