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Article

Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein.

The Journal of pathology - 1 Apr 2013

Kobos Rachel, Nagai Makoto, Tsuda Masumi, Merl Man Yee, Saito Tsuyoshi, Laé Marick, Mo Qianxing, Olshen Adam, Lianoglou Steven, Leslie Christina, Ostrovnaya Irina, Antczak Christophe, Djaballah Hakim, Ladanyi Marc

Abstract excerpt

Oncogenic rearrangements of the TFE3 transcription factor gene are found in two distinct human cancers. These include ASPSCR1-TFE3 in all cases of alveolar soft part sarcoma (ASPS) and ASPSCR1-TFE3, PRCC-TFE3, SFPQ-TFE3 and others in a subset of paediatric and adult RCCs. Here we examined the functional properties of the ASPSCR1-TFE3 fusion oncoprotein, defined its target promoters on a genome-wide basis and...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Source

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Identifiers

PMID: 23288701
DOI: 10.1002/path.4158
PMCID: PMC4083568

Genes

ASPSCR1
MET
PRCC
SFPQ
UPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein.PMID 23288701Read ↗

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