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Article

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

BMC medicine - 8 Apr 2019

Jorgensen Andrea L, Prince Clare, Fitzgerald Gail, Hanson Anita, Downing Jennifer, Reynolds Julia, Zhang J Eunice, Alfirevic Ana, Pirmohamed Munir

Abstract excerpt

BACKGROUND: Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we showed that a dosing algorithm incorporating point-of-care genotyping information ('POCT-GGD' approach) led to improved anticoagulation control. To determine whether this approach could translate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

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Source

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Identifiers

PMID: 30961588
DOI: 10.1186/s12916-019-1308-7
PMCID: PMC6454722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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