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Article

The Creating an Optimal Warfarin Nomogram (CROWN) Study.

Thrombosis and haemostasis - 1 Jan 2012

Perlstein Todd S, Goldhaber Samuel Z, Nelson Kerrie, Joshi Victoria, Morgan T Vance, Lesko Lawrence J, Lee Joo-Yeon, Gobburu Jogarao, Schoenfeld David, Kucherlapati Raju, Freeman Mason W, Creager Mark A

Abstract excerpt

A significant proportion of warfarin dose variability is explained by variation in the genotypes of the cytochrome P450 CYP2C9 and the vitamin K epoxide reductase complex, VKORC1, enzymes that influence warfarin metabolism and sensitivity, respectively. We sought to develop an optimal pharmacogenetic warfarin dosing algorithm that incorporated clinical and genetic information. We enroled patients initiating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22116191
DOI: 10.1160/TH11-08-0568
PMCID: PMC4133142

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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