Article
A Randomized Trial of Pharmacogenetic Warfarin Dosing in Naïve Patients with Non-Valvular Atrial Fibrillation.
PloS one - 1 Jan 2015
Pengo Vittorio, Zambon Carlo-Federico, Fogar Paola, Padoan Andrea, Nante Giovanni, Pelloso Michela, Moz Stefania, Frigo Anna Chiara, Groppa Francesca, Bozzato Dania, Tiso Enrico, Gnatta Elisa, Denas Gentian, Padayattil Jose Seena, Padrini Roberto, Basso Daniela, Plebani Mario
Abstract excerpt
UNLABELLED: Genotype-guided warfarin dosing have been proposed to improve patient’s management. This study is aimed to determine whether a CYP2C9- VKORC1- CYP4F2-based pharmacogenetic algorithm is superior to a standard, clinically adopted, pharmacodynamic method. Two-hundred naïve patients with non-valvular atrial fibrillation were randomized to trial arms and 180 completed the study. No significant differences...
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