Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.

doi:10.1038/323340a0

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Article

Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.

Nature - 1 Jan 2000

Reymond C D, Gomer R H, Nellen W, Theibert A, Devreotes P, Firtel R A

Abstract excerpt

The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyo...

Topics

Adenylyl Cyclases
Cell Differentiation
Dictyostelium
GTP Phosphohydrolases
GTP-Binding Proteins
Gene Expression Regulation
Genes
Mutation
Proto-Oncogenes
RNA, Messenger
Receptors, Cyclic AMP
Transformation, Genetic

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