Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein.

Nature - 3 Oct 1991

Teng D H, Engele C M, Venkatesh T R

Abstract excerpt

The X-linked prune (pn) eye-colour mutation of Drosophila melanogaster has a highly specific, complementary lethal interaction with the conditional dominant Killer of prune (awdK-pn) mutation. Although awdK-pn flies have no apparent phenotype on their own, pn awdK-pn double mutants die as second or third larval instars. The awd locus encodes a nucleoside diphosphate kinase, an enzyme that catalyses the transfer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 1654526
DOI: 10.1038/353437a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein.PMID 1654526Read ↗

Loss-of-function mutations in a glutathione S-transferase suppress the prune-Killer of prune lethal interaction.Semantic proximity Read ↗

Point mutations in awdKpn which revert the prune/Killer of prune lethal interaction affect conserved residues that are involved in nucleoside diphosphate kinase substrate binding and catalysis.Semantic proximity Read ↗

Germline transformation using a prune cDNA rescues prune/killer of prune lethality and the prune eye color phenotype in Drosophila.Semantic proximity Read ↗

Role of AWD/nucleoside diphosphate kinase in Drosophila development.Semantic proximity Read ↗

Isolation and characterization of the prune locus of Drosophila melanogaster.Semantic proximity Read ↗

Crystal structure of the Awd nucleotide diphosphate kinase from Drosophila.Semantic proximity Read ↗

prune/Killer of prune: a conditional dominant lethal interaction in Drosophila.Semantic proximity Read ↗

The mRNA product of the Drosophila gene prune is spliced and encodes a protein containing a putative transmembrane domain.Semantic proximity Read ↗

A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme.Semantic proximity Read ↗

Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.Semantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.