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Article

NAD + supplementation rejuvenates aged gut adult stem cells

27 Mar 2019

Abstract excerpt

The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ex vivo. Levels of SIRT1 and activity of mTORC1 also decline with aging. The treatment with the NAD(+) precursor nicotinamide riboside (NR) rejuvenates ISCs from...

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PMID: 30917412
DOI: 10.1111/acel.12935

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