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Article

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging.

The Journal of cell biology - 7 Aug 2017

Koehler Christopher L, Perkins Guy A, Ellisman Mark H, Jones D Leanne

Abstract excerpt

Intestinal stem cells (ISCs) maintain the midgut epithelium in Drosophila melanogaster Proper cellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate differentiation of daughter cells. However, aging and epithelial injury cause elevated ISC proliferation and decreased capacity for terminal differentiation of daughter enteroblasts (EBs). The mechanisms causing...

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Identifiers

PMID: 28663346
DOI: 10.1083/jcb.201610036
PMCID: PMC5551703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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