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Article

The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic Target

25 Nov 2016

Abstract excerpt

p53 is a sequence-specific short-lived transcription factor expressed at low concentrations in various tissues while it is upregulated in damaged, tumoral or inflamed tissue. In normally proliferating cells, p53 protein levels and function are tightly controlled by main regulators, i.e., MDM2 (mouse double minute 2) and MDM4 proteins. p53 plays an important role due to its ability to mediate tumor suppression. In...

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PMID: 27897991
DOI: 10.3390/ijms17121975

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