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Single-cell RNA sequencing identifies TGF-β as a key regenerative cue following LPS-induced lung injury

26 Mar 2019

Abstract excerpt

Many lung diseases result from a failure of efficient regeneration of damaged alveolar epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace lost cells, after which proliferation halts and some AEC2s transdifferentiate into AEC1s to restore normal alveolar structure and function. Although the mechanisms underlying AEC2 proliferation have been studied, the mechanisms...

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PMID: 30913038
DOI: 10.1172/jci.insight.123637

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