Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

16 Jul 2020

Abstract excerpt

The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed that airway and alveolar stem cells converge on a unique Krt8 + transitional stem cell state during alveolar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Diaphragmatic Hernia Studies
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32678092
DOI: 10.1038/s41467-020-17358-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosisPMID 32678092Read ↗

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read ↗

Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosisSemantic proximity Read ↗

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosisSemantic proximity Read ↗

TP53-mediated bidirectional lineage plasticity drives alveolar epithelial cell extrusion and tissue remodelingSemantic proximity Read ↗

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read ↗

Cellular plasticity and regenerative mechanisms in the lung.Semantic proximity Read ↗

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lungSemantic proximity Read ↗

Basal stem cell fate specification is mediated by SMAD signaling in the developing human lungSemantic proximity Read ↗

Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell FunctionSemantic proximity Read ↗

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regenerationSemantic proximity Read ↗

<i>Ex vivo</i> tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.