Article

Cell division tracing combined with single-cell transcriptomics reveals new cell types and differentiation paths in the regenerating mouse lung

2023-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of new therapeutic approaches for lung diseases. We combined new mouse models that allow diphtheria toxin (DTA)-mediated depletion of specific epithelial cell types and GFP-labeling of dividing cells with single-cell transcriptomics to characterize the regeneration of the distal l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1cc41f2-0057-5781-8078-1c1216362e7e
DOI: 10.1101/2023.01.18.524384

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell division tracing combined with single-cell transcriptomics reveals new cell types and differentiation paths in the regenerating mouse lungDOI 10.1101/2023.01.18.524384Read

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lungSemantic proximity Read

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regenerationSemantic proximity Read

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read

Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tractSemantic proximity Read

A smooth muscle-like niche facilitates lung epithelial regenerationSemantic proximity Read

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repairSemantic proximity Read

Stem cells and lung regenerationSemantic proximity Read

An integrated single-cell atlas of human lung across the lifespanSemantic proximity Read

A spatially-resolved blueprint of the developing human lung reveals a WNT-driven niche for basal stem cellsSemantic proximity Read

A census of the lung: CellCards from LungMAPSemantic proximity Read

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repairSemantic proximity Read