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Article

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.

Mechanisms of development - 1 Jan 2000

Golson Maria L, Le Lay John, Gao Nan, Brämswig Nuria, Loomes Kathleen M, Oakey Rebecca, May Catherine L, White Peter, Kaestner Klaus H

Abstract excerpt

Pancreatic endocrine cells originate from precursors that express the transcription factor Neurogenin3 (Ngn3). Ngn3 expression is repressed by active Notch signaling. Accordingly, mice with Notch signaling pathway mutations display increased Ngn3 expression and endocrine cell lineage allocation. To determine how the Notch ligand Jagged1 (Jag1) functions during pancreas development, we deleted Jag1 in foregut...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19501159
DOI: 10.1016/j.mod.2009.05.005
PMCID: PMC2728177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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