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Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

19 Mar 2019

Abstract excerpt

Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria in aging and neurodegenerative diseases, and the signaling pathways leading to mitochondrial biogenesis (including PGC-1 family proteins, SIRT1, AMPK) and mitophagy (parkin-Pink1 pathway). Understanding the regulation of these mitochondrial pathways may be...

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PMID: 30889315
DOI: 10.1111/cns.13116

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