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Article

Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease

19 Jan 2024

Abstract excerpt

Parkinson's disease (PD) is characterized by the degeneration of the dopaminergic neurons of the corpus striatum, which can be caused by the disruption of processes of mitochondrial homeostasis, including mitophagy, mitochondrial fusion and division, mitochondrial transport, accumulation of reactive oxygen species (ROS), and calcium signaling. Dopaminergic neurons are particularly vulnerable to mitochondrial...

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PMID: 38287806
DOI: 10.31083/j.fbl2901036

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