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In Brief: Mitophagy: mechanisms and role in human disease

25 Jul 2016

Abstract excerpt

Mitophagy is a selective form of macro-autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by eliminating dysfunctional mitochondria and reducing mitochondrial mass as an adaptive response to stress. Cells execute mitophagy through several non-redundant mechanisms, including the PINK1/Parkin partnership, which modulates...

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PMID: 27453450
DOI: 10.1002/path.4774

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