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Article

Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases

20 Oct 2022

Abstract excerpt

The selective degradation of mitochondria through mitophagy is a crucial process for maintaining mitochondrial function and cellular health. Mitophagy is a specialized form of selective autophagy that uses unique machinery to recognize and target damaged mitochondria for mitophagosome- and lysosome-dependent degradation. This process is particularly important in cells with high metabolic activity like neurons,...

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PMID: 36339819
DOI: 10.3389/fncel.2022.1031153

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