Article
Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus.
Nature microbiology - 1 Jun 2019
Yasuhara Atsuhiro, Yamayoshi Seiya, Kiso Maki, Sakai-Tagawa Yuko, Koga Michiko, Adachi Eisuke, Kikuchi Tadashi, Wang I-Hsuan, Yamada Shinya, Kawaoka Yoshihiro
Abstract excerpt
Influenza viruses possess two surface glycoproteins, haemagglutinin and neuraminidase (NA). Although haemagglutinin plays a major role as a protective antigen, immunity to NA also contributes to protection. The NA protein consists of a stalk and a head portion, the latter of which possesses enzymatic NA (or sialidase) activity. Like haemagglutinin, NA is under immune pressure, which leads to amino acid...
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