Article
Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus.
Viruses - 9 Aug 2018
Matsuzaki Yoko, Sugawara Kanetsu, Furuse Yuki, Shimotai Yoshitaka, Hongo Seiji, Mizuta Katsumi, Nishimura Hidekazu
Abstract excerpt
We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel of nine anti-HE monoclonal antibodies (MAbs), including seven of the C/Ann Arbor/1/50 virus and two of the C/Yamagata/15/2004 virus. The frequency of variant selection in the presence of anti-HE MAbs was very...
Topics
- Amino Acid Substitution
- Animals
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Antigenic Variation
- Antigens, Viral
- Binding Sites
- Epitopes
- Hemagglutination Inhibition Tests
- Hemagglutinins, Viral
- Gammainfluenzavirus
- Mice