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Article

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Scientific reports - 6 Nov 2017

Anderson Christopher S, Ortega Sandra, Chaves Francisco A, Clark Amelia M, Yang Hongmei, Topham David J, DeDiego Marta L

Abstract excerpt

The induction of antibodies specific for the influenza HA protein stalk domain is being pursued as a universal strategy against influenza virus infections. However, little work has been done looking at natural or induced antigenic variability in this domain and the effects on viral fitness. We analyzed human H1 HA head and stalk domain sequences and found substantial variability in both, although variability was...

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Identifiers

PMID: 29097696
DOI: 10.1038/s41598-017-14931-7
PMCID: PMC5668287

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