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Article

N-Linked Glycan Sites on the Influenza A Virus Neuraminidase Head Domain Are Required for Efficient Viral Incorporation and Replication.

Journal of virology - 15 Sept 2020

Östbye Henrik, Gao Jin, Martinez Mira Rakic, Wang Hao, de Gier Jan-Willem, Daniels Robert

Abstract excerpt

N-linked glycans commonly contribute to secretory protein folding, sorting, and signaling. For enveloped viruses, such as the influenza A virus (IAV), large N-linked glycans can also be added to prevent access to epitopes on the surface antigens hemagglutinin (HA or H) and neuraminidase (NA or N). Sequence analysis showed that in the NA head domain of H1N1 IAVs, three N-linked glycosylation sites are conserved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32699088
DOI: 10.1128/JVI.00874-20
PMCID: PMC7495393

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