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Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit

18 Mar 2019

Abstract excerpt

Human DNA polymerase delta (Polδ), a holoenzyme consisting of p125, p50, p68, and p12 subunits, plays an essential role in DNA replication, repair, and recombination. Herein, using multiple physicochemical and cellular approaches, we found that the p12 protein forms a dimer in solution. In vitro reconstitution and pull down of cellular Polδ by tagged p12 substantiate the pentameric nature of this critical...

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PMID: 30885984
DOI: 10.26508/lsa.201900323

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