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p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

1 Dec 2024

Abstract excerpt

Dysregulation of human DNA polymerase delta (Polδ) subunits is associated with genome instability and pathological disorders. Genome databases suggest the expression of several spliced variants of subunits which may alter Polδ function. Here, we analyzed the protein-encoding variants of the Polδ subunit p12 and their association with cancer. p12 isoform-2 (p12*) encodes a 79 aa protein with a C-terminal tail...

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PMID: 39626050
DOI: 10.1002/1873-3468.15070

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