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Article

Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.

Biochemistry - 10 Jan 2012

Rahmeh Amal A, Zhou Yajing, Xie Bin, Li Hao, Lee Ernest Y C, Lee Marietta Y W T

Abstract excerpt

DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair. Pol δ is a complex of four subunits p125, p68, p50, and p12. The functional properties of Pol δ are largely determined by its interaction with its DNA sliding clamp PCNA (proliferating cellular nuclear antigen). The regulatory mechanisms that govern the association of Pol δ with PCNA are largely unknown. In this study, we...

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Source

Identifiers

PMID: 22148433
DOI: 10.1021/bi201638e

Genes

PCNA
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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