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Article

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

14 Jun 2007

Abstract excerpt

Androgen receptor (AR) is essential for the growth and progression of prostate cancer in both hormone-sensitive and hormone-refractory disease. A DNA-binding polyamide that targets the consensus androgen response element binds the prostate-specific antigen (PSA) promoter androgen response element, inhibits androgen-induced expression of PSA and several other AR-regulated genes in cultured prostate cancer cells,...

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Identifiers

PMID: 17566103
DOI: 10.1073/pnas.0704217104

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