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Article

Recognition and Accommodation at the Androgen Receptor Coactivator Binding Interface

12 Aug 2004

Abstract excerpt

Prostate cancer is a leading killer of men in the industrialized world. Underlying this disease is the aberrant action of the androgen receptor (AR). AR is distinguished from other nuclear receptors in that after hormone binding, it preferentially responds to a specialized set of coactivators bearing aromatic-rich motifs, while responding poorly to coactivators bearing the leucine-rich "NR box" motifs favored by...

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PMID: 15328534
DOI: 10.1371/journal.pbio.0020274

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