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Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

14 Feb 2019

Abstract excerpt

Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the skin with overlapping histologic features and unspecific molecular traits. PDS behaves aggressive compared to AFX. Thus, a precise delineation, although challenging in some instances, is relevant. We examined the value of DNA-methylation profiling and copy number analysis for separating these tumors. DNA-methylation data were...

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PMID: 30809375
DOI: 10.1186/s13569-019-0113-6

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