Article
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations.
Human pathology - 1 Aug 2020
Miller Timothy I, Zoumberos Nicholas A, Johnson Bryan, Rhodes Daniel R, Tomlins Scott A, Chan May P, Andea Aleodor A, Lucas David R, McHugh Jonathan B, Smith Noah, Harms Kelly L, Brewer Chad, Saleh Jasmine, Patel Rajiv M, Harms Paul W
Abstract excerpt
Sarcomas on photodamaged skin vary in prognosis and management, but can display overlapping microscopic and immunophenotypic features. Improved understanding of molecular alterations in these tumors may provide diagnostic and therapeutic insights. We characterized 111 cutaneous sarcomatoid malignancies and their counterparts, including primary cutaneous angiosarcoma (n = 7), atypical fibroxanthoma (AFX) (n = 21),...
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